Upper airway resistance syndrome (UARS) is a condition often overshadowed by its more recognized counterparts, such as obstructive sleep apnea (OSA). Yet, this disorder has a profound impact on the sleep quality and daily functioning of those who suffer from it. Patients with UARS experience heightened resistance to airflow during sleep and present symptoms akin to both OSA and habitual snoring, but with distinct diagnostic criteria and treatments. With effects like disrupted sleep patterns and chronic fatigue, the repercussions of UARS extend beyond the night, influencing daytime performance and well-being. Whether you're seeking clarity on your own symptoms or aiming to understand a loved one's struggles, we will explore the symptoms, causes, diagnosis, and treatment options for UARS, offering insights into the potential consequences if left untreated.

woman sleeping

What Is Upper Airway Resistance Syndrome (UARS)?

Upper Airway Resistance Syndrome (UARS) was initially recognized and described at Stanford University. It shares similarities with obstructive sleep apnea (OSA) in terms of the relaxation of soft throat tissues, which leads to a narrowing of the airway during sleep. The narrowing results in disrupted sleep patterns and subsequent daytime impairment, including excessive daytime sleepiness. While UARS resembles OSA, the increase in upper airway resistance experienced in UARS does not meet the criteria for diagnosing obstructive sleep apnea. However, the heightened effort required for breathing during episodes of increased resistance often triggers brief awakenings from sleep, which frequently go unnoticed by the person affected. The interruptions to sleep during UARS, although brief, occur repeatedly throughout the night and cause impaired sleep quality similar to that seen in obstructive sleep apnea.

How Can Patients Know If They Suffer From UARS?

Determining whether one suffers from upper airway resistance syndrome can be challenging due to its symptom overlap with obstructive sleep apnea. While the symptoms of UARS closely resemble those of OSA, they are often milder in intensity. One hallmark sign of UARS is frequent arousals from sleep, often triggered by the increased effort required for breathing due to narrowed airways. Those affected by UARS also commonly report the following:

  • Snoring
  • Daytime sleepinessCognitive impairment
  • Un-refreshing sleep
  • Frequent waking during the night

Given the similarities between UARS and OSA, people experiencing these symptoms are encouraged to seek evaluation by a healthcare professional specializing in sleep disorders. A comprehensive assessment, including a detailed medical history and a sleep study, can aid in diagnosing UARS and determining appropriate management strategies.

Can UARS Be Treated?

While upper airway resistance syndrome continues to be studied and understood, treatment options are available to alleviate symptoms and improve sleep quality.

Positive Airway Pressure (PAP) Therapy

Positive airway pressure (PAP) therapy, such as continuous positive airway pressure (CPAP), is a primary treatment for upper airway resistance syndrome. With CPAP therapy, individuals wear a specialized mask during sleep, connected to a machine that delivers a continuous stream of air into the upper airway. The air pressure helps prevent the collapse of soft throat tissues, maintaining an open airway and facilitating regular breathing throughout the night.

Oral Appliances

For individuals who cannot tolerate PAP therapy, oral appliances offer an alternative treatment option for UARS. These devices, worn during sleep, work to prevent the collapse of soft throat tissues by repositioning the jaw or tongue.

Surgical Interventions

In some cases, surgical interventions may be necessary to address upper airway resistance syndrome. Surgical procedures aim to enlarge the airway, reducing the likelihood of collapse during sleep. Surgical options vary depending on individual needs and may involve procedures such as:

  • Uvulopalatopharyngoplasty: During UPPP, excess tissue from the throat is removed to widen the airway and reduce obstruction during sleep. The surgery involves removing the uvula, as well as part of the soft palate and any excess tissue from the pharynx.
  • Maxillomandibular advancement: MMA refers to repositioning the upper and lower jaws forward to widen the upper airway and reduce obstruction during sleep. This surgery addresses anatomical abnormalities that contribute to airway narrowing and obstruction, such as a small or retruded lower jaw or a recessed upper jaw.

Weight Loss

Weight loss can be an effective adjunctive treatment for UARS, particularly when combined with other therapeutic approaches. Excess weight can lead to increased deposition of fat around the upper airway, resulting in airway narrowing and exacerbating symptoms of upper airway resistance syndrome. By achieving and maintaining a healthy weight through diet and exercise, individuals may experience improvements in airway function and reduction in symptoms.

couple sleeping and one using a CPAP machine

Are You Seeking Treatment for Upper Airway Resistance Syndrome?

For professional assistance in diagnosing and treating Upper Airway Resistance Syndrome (UARS), we encourage you to reach out to the specialists at Sunrise Orthodontics and Airway and Sleep Group. Contact us today to schedule an appointment or learn more!

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